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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: C3 All Species: 16.06
Human Site: S287 Identified Species: 39.26
UniProt: P01024 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P01024 NP_000055.2 1663 187148 S287 Q R I S L P E S L K R I P I E
Chimpanzee Pan troglodytes XP_512318 1139 127558
Rhesus Macaque Macaca mulatta XP_001091921 1500 169769 E265 T K K R E L S E A E Q A T R T
Dog Lupus familis XP_533932 1549 174079 S287 R R I S L S Q S L T R I L I E
Cat Felis silvestris
Mouse Mus musculus P01027 1663 186464 S288 K K I S L A H S L T R V V I E
Rat Rattus norvegicus P01026 1663 186442 S287 K K I S L A L S L T R V L I E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505969 1653 185840 S283 G K K S I P A S L S R V Q I M
Chicken Gallus gallus P20740 1473 166336 P238 L V E E Y V L P K F D V T V T
Frog Xenopus laevis NP_001080934 1683 189689 L297 K R Y M L R G L E K Q T T L I
Zebra Danio Brachydanio rerio NP_571318 1651 184738 S292 A K T S I V N S L Q K V P V V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 64.4 79.9 68.7 N.A. 77.1 78.1 N.A. 62.9 21.8 31.7 43.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 65.7 83 80.5 N.A. 87.9 88.5 N.A. 78.2 41 53.1 62.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 0 66.6 N.A. 53.3 53.3 N.A. 40 0 20 26.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 0 20 80 N.A. 73.3 73.3 N.A. 60 13.3 40 66.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 0 20 10 0 10 0 0 10 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % D
% Glu: 0 0 10 10 10 0 10 10 10 10 0 0 0 0 40 % E
% Phe: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % F
% Gly: 10 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 40 0 20 0 0 0 0 0 0 20 0 50 10 % I
% Lys: 30 50 20 0 0 0 0 0 10 20 10 0 0 0 0 % K
% Leu: 10 0 0 0 50 10 20 10 60 0 0 0 20 10 0 % L
% Met: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 10 % M
% Asn: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 20 0 10 0 0 0 0 20 0 0 % P
% Gln: 10 0 0 0 0 0 10 0 0 10 20 0 10 0 0 % Q
% Arg: 10 30 0 10 0 10 0 0 0 0 50 0 0 10 0 % R
% Ser: 0 0 0 60 0 10 10 60 0 10 0 0 0 0 0 % S
% Thr: 10 0 10 0 0 0 0 0 0 30 0 10 30 0 20 % T
% Val: 0 10 0 0 0 20 0 0 0 0 0 50 10 20 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 10 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _